Description

1-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxamide is a high-value, advanced pharmaceutical intermediate featuring a cyclopropane carboxamide core linked to a protected boronic ester moiety. This compound is specifically engineered for use in modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, which are fundamental to constructing complex molecules. It is a critical building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for therapeutic areas such as oncology, neurology, and metabolic diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: The tetramethyl dioxaborolane (pinacol boronic ester) group serves as a stable, protected handle for palladium-catalyzed carbon-carbon bond formation, enabling the construction of biaryl and other complex molecular architectures.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific, complex chemical scaffolds.
• Material Science Research: Acts as a monomer or functionalization agent in the development of advanced organic electronic materials, such as polymers for OLEDs or sensors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research laboratories for custom synthesis projects requiring specific, high-purity boronic ester derivatives.

Basic Information

Item	Detail
Product Name	1-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxamide
CAS No.	1628010-77-4
Molecular Formula	C16H22BNO3
Molecular Weight	287.16 g/mol
Synonyms	3-(1-Carbamoylcyclopropyl)phenylboronic acid pinacol ester; 1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxamide; 3-(Cyclopropanecarboxamido)phenylboronic acid pinacol ester; (3-(1-Carbamoylcyclopropyl)phenyl)boronic acid pinacol ester; B-[3-(1-Carbamoylcyclopropyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1628010-77-4; Cyclopropanecarboxamide, 1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
EINECS	Contact for details

Quality Control

Our 1-[3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.