Description

tert-Butyl 2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate is a high-value, protected indole boronic ester building block essential for modern synthetic chemistry. This compound matters because it provides a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need it for the development of new active ingredients and functional molecules, leveraging its versatility in creating carbon-carbon bonds under mild conditions.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel indole-based drug candidates in oncology, CNS, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the creation of new herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science: Serves as a precursor for organic electronic materials, such as OLEDs and conductive polymers.
• Academic & Contract Research: Enables methodology development and library synthesis for discovery chemistry in academic and CRO laboratories.
• Peptidomimetics & Bioconjugation: Facilitates the synthesis of indole-containing peptide analogs and bioconjugates for chemical biology.
• Catalyst Ligand Synthesis: Used to prepare sophisticated ligand frameworks for transition metal catalysis.

Basic Information

Product Name	tert-Butyl 2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate
CAS No.	1627721-62-3
Molecular Formula	C20H28BNO4
Molecular Weight	357.25 g/mol
Synonyms	1-Boc-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; tert-Butyl 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic acid tert-butyl ester; 3-Borono-2-methyl-1H-indole-1-carboxylic acid tert-butyl ester, pinacol ester; Boc-2-Me-3-Bpin-indole
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.