Description

tert-Butyl 2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenylamino)ethylcarbamate is a high-purity, protected amine-containing boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in providing a versatile, reactive handle for Suzuki-Miyaura cross-coupling reactions while offering orthogonal protection for the amine functionality. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the development of novel small molecule therapeutics and advanced materials. The CAS number for this compound is 1627580-07-7.

Application

This advanced chemical intermediate is designed for precision synthesis in research and development. Key application areas include:

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, particularly in creating biaryl and heterobiaryl structures common in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel active ingredients, such as herbicides and fungicides, requiring specific aryl-aryl linkages.
• Material Science Research: Employed in the creation of organic electronic materials, including polymers and small molecules for OLEDs and OFETs, where precise molecular architecture is crucial.
• Chemical Biology & Proteomics: Serves as a valuable reagent for synthesizing probes and linkers used in activity-based protein profiling and bioconjugation strategies.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel construction of diverse compound libraries via cross-coupling, accelerating hit identification and lead optimization campaigns.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing novel bidentate or tridentate ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Item	Details
Product Name	tert-Butyl 2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenylamino)ethylcarbamate
CAS No.	1627580-07-7
Molecular Formula	C19H31BN2O4
Molecular Weight	362.27 g/mol
Synonyms	N-Boc-N'-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethylenediamine; 2-[(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amino]ethyl carbamic acid tert-butyl ester; tert-Butyl N-[2-[[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]amino]ethyl]carbamate; 3-(2-((tert-Butoxycarbonyl)amino)ethylamino)phenylboronic acid pinacol ester; BOC-EDA-3-BPin
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenylamino)ethylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.