Description

1,2,3,4-Tetrahydroquinoline-6-Boronic Acid, Pinacol Ester is a high-value, protected boronic acid derivative crucial for modern synthetic chemistry. This compound serves as a key Suzuki-Miyaura cross-coupling partner, enabling the efficient construction of complex heterocyclic scaffolds. It is essential for researchers and process chemists in pharmaceutical, agrochemical, and advanced materials R&D who require reliable, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly those containing the tetrahydroquinoline pharmacophore, which is prevalent in compounds with CNS, anticancer, and antimicrobial activity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the boronic ester functionality allows for the introduction of the quinoline moiety into complex molecules.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and conductive polymers, where its structure can be incorporated to modify electronic properties.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions to form carbon-carbon bonds, a cornerstone methodology in modern organic synthesis.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Used to create tagged molecules and probes for studying biological pathways and protein interactions.

Basic Information

Product Name	1,2,3,4-Tetrahydroquinoline-6-Boronic Acid, Pinacol Ester
CAS No.	1627563-96-5
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydroquinolin-6-ylboronic acid pinacol ester; 6-(Pinacolboryl)-1,2,3,4-tetrahydroquinoline; Tetrahydroquinoline-6-boronic acid pinacol ester; Quinoline, 1,2,3,4-tetrahydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 6-Borono-1,2,3,4-tetrahydroquinoline pinacol ester; THQ-6-Bpin
EINECS	Contact for details

Quality Control

Every batch of 1,2,3,4-Tetrahydroquinoline-6-Boronic Acid, Pinacol Ester is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical research and development. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards and your specific project requirements. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to maximize shelf life and maintain purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.