Description

1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the introduction of the 1-ethyl-1,2,3,6-tetrahydropyridinyl moiety into complex molecular architectures.
• Agrochemical Research: Used in the discovery and development of new active ingredients for crop protection and pest management.
• Material Science: Potential precursor for the synthesis of organic electronic materials and ligands for catalysis.
• Chemical Biology: Employed in the synthesis of probes and tool compounds for target identification and validation.
• Process Chemistry: Scalable intermediate for the commercial production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine
CAS No.	1627158-64-8
Molecular Formula	C13H24BNO2
Molecular Weight	237.15 g/mol
Synonyms	1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydro-pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-ethyl-1,2,3,6-tetrahydropyridine; 1-Ethyl-4-(pinacolatoboryl)-1,2,3,6-tetrahydropyridine; 1-Ethyl-4-(pinacolboron)-1,2,3,6-tetrahydropyridine; 1-Ethyl-4-(pinacolato)boryl-1,2,3,6-tetrahydropyridine; 1-Ethyl-4-(pinacol boronate)-1,2,3,6-tetrahydropyridine; 1-Ethyl-4-(pinacol boronic ester)-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our 1-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Typical 97-99%)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.