Description

3-Methoxy-4-(trifluoromethoxy)phenylboronic acid pinacol ester is a high-purity, synthetically valuable organoboron reagent. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form, which is critical for complex synthetic workflows. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex molecules in drug discovery and development, particularly for active pharmaceutical ingredients (APIs) containing substituted biphenyl motifs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the trifluoromethoxy and methoxy substituents confer desirable biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or intermediate in the development of advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a scaffold in metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological systems and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences market.

Basic Information

Product Name	3-Methoxy-4-(trifluoromethoxy)phenylboronic acid pinacol ester
CAS No.	1623766-74-4
Molecular Formula	C₁₄H₁₈BF₃O₄
Molecular Weight	318.10 g/mol
Synonyms	[4-(Trifluoromethoxy)-3-methoxyphenyl]boronic acid pinacol ester; 3-Methoxy-4-trifluoromethoxyphenylboronic acid pinacol ester; Pinacol [3-methoxy-4-(trifluoromethoxy)phenyl]boronate; B-[3-Methoxy-4-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-Methoxy-4-(trifluoromethoxy)phenyl)boronic acid pinacol ester; 1623766-74-4; Boronic acid, B-[3-methoxy-4-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 3-Methoxy-4-(trifluoromethoxy)phenylboronic acid pinacol ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. All materials undergo comprehensive analytical characterization, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) documenting these results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.