Description

tert-Butyl (2R)-2-Formyl-2-Methylpyrrolidine-1-Carboxylate is a high-purity, chiral building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the development of proprietary chiral ligands and organocatalysts.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure pesticides and herbicides.
• Peptidomimetic Chemistry: Employed in the construction of proline-derived peptidomimetics and conformationally constrained amino acid analogs.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.
• Custom Synthesis Projects: Provides a versatile handle for contract research and manufacturing organizations (CROs/CMOs) working on custom chiral molecules.

Basic Information

Product Name	tert-Butyl (2R)-2-Formyl-2-Methylpyrrolidine-1-Carboxylate
CAS No.	1623409-38-0
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	1-Boc-2(R)-Formyl-2-Methylpyrrolidine; (R)-1-(tert-Butoxycarbonyl)-2-formyl-2-methylpyrrolidine; (2R)-1-(tert-Butoxycarbonyl)-2-formyl-2-methylpyrrolidine; tert-Butyl (R)-2-formyl-2-methylpyrrolidine-1-carboxylate; Boc-(R)-2-Formyl-2-methylpyrrolidine; (R)-2-Formyl-2-methylpyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (2R)-2-Formyl-2-Methylpyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR, IR) are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. For long-term storage, keep the material in a cool, dry, and well-ventilated area separate from incompatible substances. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.