Description

2,4-Dichloropyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyridine-based drug candidates, including kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides that require specific chloropyridine motifs for bioactivity.
• Material Science Research: Serves as a precursor for creating functionalized ligands in catalysis, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Employed to synthesize molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke chemicals for client projects.
• Academic & Discovery Chemistry: Facilitates rapid library synthesis in medicinal chemistry and methodology development within university and industrial research labs.

Basic Information

Product Name	2,4-Dichloropyridine-5-Boronic Acid Pinacol Ester
CAS No.	1622217-00-8
Molecular Formula	C11H12BCl2NO2
Molecular Weight	272.94 g/mol
Synonyms	5,5-Dimethyl-2-(2,4-dichloropyridin-5-yl)-1,3,2-dioxaborinane; 2,4-Dichloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2,4-Dichloropyridin-5-yl)boronic acid pinacol ester; 2,4-Dichloro-5-pyridineboronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-dichloropyridine; 2,4-Dichloro-5-(pinacolboranyl)pyridine; Boronic acid, B-(2,4-dichloro-5-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2,4-Dichloropyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques (NMR, HPLC, GC). Our quality commitment aligns with the standards required for cGMP (current Good Manufacturing Practice) starting material applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container for extended periods to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.