Description

4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole is a high-value, advanced pharmaceutical intermediate and building block featuring a protected boronic ester group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and materials science. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and organic electronics sectors for the synthesis of complex, biologically active molecules and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in constructing complex heterocyclic cores prevalent in CNS and oncology therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds under mild conditions, essential for creating biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its ability to introduce complex indole-based motifs.
• Material Science & Organic Electronics: Employed in the synthesis of conjugated polymers and small molecules for applications in OLEDs, OFETs, and sensors.
• Chemical Biology & Probe Development: Utilized as a precursor for creating molecular probes and labeled compounds for target identification and binding studies.
• Process Chemistry & Scale-up: Provides a stable, crystalline form of the boronate for reliable and scalable manufacturing processes in GMP and non-GMP environments.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole
CAS No.	1622173-47-0
Molecular Formula	C14H20BNO2
Molecular Weight	245.13 g/mol
Synonyms	2,3-Dihydro-1H-indol-4-ylboronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole; 4-Boronic acid pinacol ester-2,3-dihydroindole; 4-Indolineboronic acid pinacol ester; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)indoline; 4-Pinacolatoboryl-2,3-dihydro-1H-indole; N-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole (protected form)
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maximize long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.