Description

4-Chloro-3-(Cyclopropylaminocarbonyl)Phenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a cyclopropylamide moiety, enabling the construction of complex, pharmaceutically relevant scaffolds. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile organoboron reagent for constructing biaryl and heterobiaryl structures, a cornerstone reaction in medicinal chemistry.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the cyclopropane pharmacophore.
• Material Science: Potential building block for creating advanced organic electronic materials and metal-organic frameworks (MOFs) via its coupling and complexation capabilities.
• Chemical Biology & Proteomics: Can be utilized in the development of activity-based probes and covalent inhibitors due to its reactive boronic ester group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from research to pilot plant.

Basic Information

Product Name	4-Chloro-3-(Cyclopropylaminocarbonyl)Phenylboronic Acid Pinacol Ester
CAS No.	1621438-71-8
Molecular Formula	C₁₆H₂₁BClNO₃
Molecular Weight	321.61 g/mol
Synonyms	4-Chloro-3-[(cyclopropylamino)carbonyl]benzeneboronic Acid Pinacol Ester; 2-(4-Chloro-3-(cyclopropylcarbamoyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-Chloro-3-(cyclopropylcarbamoyl)phenyl)boronic Acid Pinacol Ester; 3-Carbamoyl-4-chlorophenylboronic Acid Pinacol Ester (cyclopropyl variant); B-[4-Chloro-3-(cyclopropylaminocarbonyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1621438-71-8; Cyclopropylamide Phenylboronic Ester Derivative
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-(Cyclopropylaminocarbonyl)Phenylboronic Acid Pinacol Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analysis including HPLC purity determination, NMR structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality system is designed to support cGMP and ISO 9001 standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation to prevent hydrolysis of the boronic ester group. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.