Description

n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Ethanesulfonamide is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel small molecule therapeutics, agrochemicals, and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key building block for constructing biaryl and heterobiaryl scaffolds in pharmaceutical active ingredients.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) disease targets.
• Agrochemical Synthesis: Intermediate for creating advanced herbicides, fungicides, and insecticides with complex aromatic structures.
• Material Science Research: Serves as a precursor for synthesizing organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the development of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Process Chemistry & Scale-up: Employed in the optimization and commercial-scale production of APIs (Active Pharmaceutical Ingredients).

Basic Information

Product Name	n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Ethanesulfonamide
CAS No.	1621415-43-7
Molecular Formula	C14H22BNO4S
Molecular Weight	311.21 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(ethylsulfonyl)aniline; N-Ethylsulfonyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 2-(Pinacolatoboran-2-yl)-N-ethylsulfonylaniline; Ethanesulfonamide, N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; CAS 1621415-43-7; Boronic ester intermediate 1621415-43-7; Aryl pinacol boronate sulfonamide
EINECS	Contact for details

Quality Control

Our n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Ethanesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.