Description

(2R,3R,4R,5S,6R)-2-(Acetoxymethyl)-6-(4-Chloro-3-(4-(((S)-Tetrahydrofuran-3-Yl)Oxy)Benzyl)Phenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate is a high-purity, synthetically derived chemical intermediate characterized by its complex stereochemistry and functionalized structure. This compound is of significant value in pharmaceutical research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology industries working on advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly in metabolic and cardiovascular disease research.
• Process Chemistry Development: Used for route scouting, optimization, and scale-up studies for new chemical entities (NCEs).
• Glycoscience Research: Serves as a sophisticated substrate or inhibitor in studies involving glycosidase enzymes or carbohydrate-based signaling pathways.
• Chemical Biology Probe Synthesis: Employed to create tool compounds for investigating biological targets and mechanisms of action.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in API manufacturing.
• Custom Synthesis Building Block: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.

Basic Information

Product Name	(2R,3R,4R,5S,6R)-2-(Acetoxymethyl)-6-(4-Chloro-3-(4-(((S)-Tetrahydrofuran-3-Yl)Oxy)Benzyl)Phenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate
CAS No.	1620758-27-1
Molecular Formula	C29H31ClO11
Molecular Weight	591.00 g/mol
Synonyms	Dapagliflozin Impurity 66; Dapagliflozin Related Compound 66; (2R,3R,4R,5S,6R)-2-(Acetoxymethyl)-6-[4-Chloro-3-[[4-[[(3S)-Tetrahydrofuran-3-yl]oxy]phenyl]methyl]phenyl]tetrahydro-2H-pyran-3,4,5-triyl Triacetate; 1-(Chlorophenyl)-4-[(S)-tetrahydrofuran-3-yloxy]benzyl-β-D-glucopyranose Pentaacetate; DAPA Impurity 66; Forxiga Impurity 66; Farxiga Impurity 66; SGLT2 Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our (2R,3R,4R,5S,6R)-2-(Acetoxymethyl)-6-(4-Chloro-3-(4-(((S)-Tetrahydrofuran-3-Yl)Oxy)Benzyl)Phenyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines for pharmaceutical intermediates, ensuring reliable supply for your critical R&D and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Single Maximum Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.