Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethoxy)Pyridin-2-Amine (Wx192479) is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. This compound is valued for its role in facilitating key carbon-carbon bond-forming reactions, enabling the efficient synthesis of complex molecular architectures. It is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require the incorporation of the trifluoromethoxy-pyridine motif.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and advanced intermediates under cGMP conditions where required.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethoxy)Pyridin-2-Amine (Wx192479)
CAS No.	1620575-08-7
Molecular Formula	C12H16BF3N2O3
Molecular Weight	304.08 g/mol
Synonyms	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethoxy)pyridine; 3-(Trifluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; WX-192479; 1620575-08-7; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethoxy)pyridin-2-amine; Pinacol ester of [2-Amino-3-(trifluoromethoxy)pyridin-5-yl]boronic acid.
EINECS	Contact for details

Quality Control

Every batch of 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethoxy)Pyridin-2-Amine undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality systems are designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically >95% by HPLC), identity confirmation (by 1H/13C NMR, IR, and MS), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool, and well-ventilated place. Due to its hygroscopic and easily oxidized nature, prolonged exposure to air, moisture, or ambient light should be avoided. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (1H & 13C)
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.