Description

Cyclopropyl(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridin-1(2H)-Yl)Methanone is a high-value boronic ester derivative, serving as a critical advanced pharmaceutical intermediate in modern organic synthesis. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex carbon-carbon bonds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS (Central Nervous System) therapeutic research.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides by facilitating the introduction of the cyclopropyl and dihydropyridine motifs.
• Material Science Research: Employed in the synthesis of organic electronic materials and ligands for catalysis due to its unique boronate functional group.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura coupling with aryl or vinyl halides to create complex biaryl and conjugated structures.
• Medicinal Chemistry Library Construction: A versatile scaffold for generating diverse compound libraries for high-throughput screening in drug discovery.
• Chemical Biology Probes: Can be used to create labeled molecules or probes for studying biological pathways and target engagement.

Basic Information

Product Name	Cyclopropyl(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridin-1(2H)-Yl)Methanone
CAS No.	1616388-38-5
Molecular Formula	C19H28BNO3
Molecular Weight	329.24 g/mol
Synonyms	1-(Cyclopropylcarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; Cyclopropyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methanone; 1-(Cyclopropylcarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(cyclopropylcarbonyl)-1,2,3,6-tetrahydropyridine; 1616388-38-5; Cyclopropyl(4-(pinacolatoboryl)-1,2,3,6-tetrahydropyridin-1-yl)methanone
EINECS	Contact for details

Quality Control

Our production of Cyclopropyl(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridin-1(2H)-Yl)Methanone adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization including NMR, HPLC, and mass spectrometry to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive (hygroscopic) nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.