Description

2-(2,6-Difluoro-3,5-Dimethoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient and selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, active ingredient synthesis, and functional material development.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that incorporate difluoromethoxy phenyl motifs for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Diagnostics: Employed in the synthesis of probes and labeling reagents that target specific biological pathways.
• Academic & Process R&D: A valuable reagent for method development and scaling novel synthetic routes in academic and industrial research laboratories.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals for client projects.

Basic Information

Product Name	2-(2,6-Difluoro-3,5-Dimethoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1614233-69-0
Molecular Formula	C₁₄H₁₉BF₂O₄
Molecular Weight	312.11 g/mol
Synonyms	2,6-Difluoro-3,5-dimethoxyphenylboronic acid pinacol ester; (2,6-Difluoro-3,5-dimethoxyphenyl)boronic acid pinacol ester; 2,6-Difluoro-3,5-dimethoxybenzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2,6-difluoro-3,5-dimethoxyphenyl)-1,3,2-dioxaborolane; 1614233-69-0; DifluorodimethoxyphenylBPin; Pinacol (2,6-difluoro-3,5-dimethoxyphenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-(2,6-Difluoro-3,5-Dimethoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and reliability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation, as boronic esters can be sensitive to hydrolysis. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.