Description

3-(Difluoromethyl)Cyclobutane-1-Carboxylic Acid is a high-purity, versatile cyclobutane derivative featuring a difluoromethyl group, making it a valuable fluorinated building block for advanced synthesis. Its unique structure is critical for modulating the physicochemical properties of target molecules, particularly in enhancing metabolic stability and lipophilicity. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorinated cyclobutane motifs.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in protease inhibitors and kinase-targeted therapies.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the difluoromethyl group can improve biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, influencing dielectric anisotropy and stability.
• Fluorinated Polymer Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) explorations to investigate the impact of the fluorinated cyclobutane core on potency and selectivity.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated carbocyclic structures.

Basic Information

Product Name	3-(Difluoromethyl)Cyclobutane-1-Carboxylic Acid
CAS No.	1613330-49-6
Molecular Formula	C6H8F2O2
Molecular Weight	150.12 g/mol
Synonyms	3-(Difluoromethyl)cyclobutane-1-carboxylic acid; 3-(Difluoromethyl)cyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 3-(difluoromethyl)-; 1-Carboxy-3-(difluoromethyl)cyclobutane; 1613330-49-6; 3-Difluoromethyl-cyclobutanecarboxylic acid; 3-(Difluoromethyl)-1-cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethyl)Cyclobutane-1-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and sources of fluoride ions. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.