Description

Isobenzofuran, 1,3-Dihydro-1,1-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a specialized organoboron building block of significant value in modern synthetic chemistry. Its core value proposition lies in its dual functionality, combining a reactive isobenzofuran core with a protected boronic ester group, enabling efficient cross-coupling reactions and complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for developing active pharmaceutical ingredients (APIs), novel crop protection agents, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of complex biaryl and heterobiaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in constructing novel active ingredients for herbicides, fungicides, and insecticides through efficient boron-based coupling methodologies.
• Material Science Research: Serves as a monomer or building block for developing organic semiconductors, luminescent materials, and polymers with tailored electronic properties.
• Chemical Biology & Probe Development: Enables the labeling and modification of biomolecules for diagnostic and research applications.
• Catalyst & Ligand Development: Employed in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	Isobenzofuran, 1,3-Dihydro-1,1-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1613260-40-4
Molecular Formula	C16H23BO3
Molecular Weight	274.17 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-1,1-dimethylisobenzofuran; 1,1-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydroisobenzofuran; 1,3-Dihydro-1,1-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isobenzofuran; Pinacol 1,1-dimethyl-1,3-dihydroisobenzofuran-5-boronate; 1,1-Dimethylisobenzofuran-5-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our Isobenzofuran, 1,3-Dihydro-1,1-Dimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.