Description

1-Boc-4,4-Dimethyl-Pyrrolidine-2-Carboxylic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a sterically hindered, chiral proline-like scaffold with orthogonal protecting groups, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptidomimetics, protease inhibitors, and other drug candidates targeting neurological and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides and fungicides that require specific stereochemistry for optimal activity.
• Peptide Chemistry: Serves as a constrained, non-natural amino acid analog to introduce conformational rigidity into peptide chains, improving stability and bioavailability.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research.

Basic Information

Product Name	1-Boc-4,4-Dimethyl-Pyrrolidine-2-Carboxylic Acid
CAS No.	1613115-21-1
Molecular Formula	C₁₂H₂₁NO₄
Molecular Weight	243.30 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4,4-dimethylpyrrolidine-2-carboxylic acid; 4,4-Dimethyl-1-Boc-pyrrolidine-2-carboxylic Acid; (4,4-Dimethylpyrrolidin-1-yl)-2-carboxylic acid tert-butyl ester; tert-Butyl 4,4-dimethyl-2-carboxypyrrolidine-1-carboxylate; 1-Boc-4,4-dimethyl-DL-proline; Boc-4,4-Dimethylproline; 1-Boc-4,4-dimethylproline
EINECS	Contact for details

Quality Control

Our 1-Boc-4,4-Dimethyl-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.