Description

2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanenitrile is a high-value, functionalized pyrazole-boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for drug discovery, active ingredient synthesis, and functional polymer development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific pyrazole-based structures.
• Material Science: Serves as a monomer or precursor for creating functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the development of molecular probes, enzyme inhibitors, and bioconjugation reagents for target identification and validation.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in university and CRO (Contract Research Organization) laboratories.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale synthesis under GMP-like conditions for clinical trial material production.

Basic Information

Product Name	2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanenitrile
CAS No.	1612174-34-1
Molecular Formula	C₁₂H₁₈BN₃O₂
Molecular Weight	247.11 g/mol
Synonyms	2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile; 1H-Pyrazole-1-propanenitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Propanenitrile, 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-; 2-(4-(Pinacolatoboryl)-1H-pyrazol-1-yl)propanenitrile; 4-(Pinacolatoboryl)-1-(1-cyanoethyl)-1H-pyrazole; 1612174-34-1; Pyrazole boronic ester pinacol derivative
EINECS	Contact for details

Quality Control

Our 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support customer audits and can tailor quality documentation to meet specific regulatory or internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize moisture uptake. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.