Description

1-(Cyclopropanesulfonyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate and a versatile boronic ester building block. This compound is critical for enabling modern synthetic methodologies, particularly in cross-coupling reactions for constructing complex molecules. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex heterocyclic compounds and biaryl structures.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of new active pharmaceutical ingredients (APIs), especially those containing pyrazole and sulfonyl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysis, and other functional organic molecules.
• Medicinal Chemistry & Drug Discovery: Facilitates rapid analog synthesis and structure-activity relationship (SAR) studies in lead optimization programs.
• Chemical Biology Probes: Acts as a precursor for synthesizing tagged molecules used to study biological pathways and protein interactions.

Basic Information

Product Name	1-(Cyclopropanesulfonyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1612172-62-9
Molecular Formula	C11H19BN2O4S
Molecular Weight	286.16 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(cyclopropylsulfonyl)-1H-pyrazole; 1-(Cyclopropylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Cyclopropanesulfonyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-(cyclopropylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(cyclopropanesulfonyl)pyrazole; Boron, [1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl-; CAS 1612172-62-9
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Quality Control

Our 1-(Cyclopropanesulfonyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.