Description

Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-2-Carboxylate CAS NO 1610705-51-5 is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its role as a versatile intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyrimidine cores.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that leverage pyrimidine chemistry.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and bioconjugation reagents due to its reactive boronate group.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in cross-coupling chemistry and heterocycle synthesis.
• Scale-up Process Chemistry: Suitable for process development and pilot-scale synthesis under controlled GMP-like conditions for critical intermediates.

Basic Information

Product Name	Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-2-Carboxylate
CAS No.	1610705-51-5
Molecular Formula	C12H19BN2O4
Molecular Weight	266.11 g/mol
Synonyms	Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-carboxylate; 2-Pyrimidinecarboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-carboxylic acid methyl ester; Methyl 5-(pinacolatoboran-2-yl)pyrimidine-2-carboxylate; 5-(Pinacolatoboryl)pyrimidine-2-carboxylic acid methyl ester; Methyl 5-(pinacolboronato)pyrimidine-2-carboxylate; 1610705-51-5
EINECS	Contact for details

Quality Control

Our Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced applications and can tailor quality documentation to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.