Description

4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Aniline is a specialized aromatic amine derivative featuring a photoreactive diazirine group and a trifluoromethyl substituent. This unique bifunctional structure makes it a critical intermediate for the synthesis of photoaffinity labeling probes and cross-linking agents used in advanced biochemical research. It is primarily required by pharmaceutical R&D and life science organizations for investigating protein-ligand interactions, target identification, and mapping biological binding sites.

Application

• Photoaffinity Labeling (PAL): A key building block for synthesizing PAL probes to capture transient biomolecular interactions.
• Chemical Biology Research: Used in the development of covalent inhibitors and activity-based protein profiling (ABPP) reagents.
• Proteomics & Target Identification: Enables the covalent cross-linking of drug candidates to their protein targets for identification and validation.
• Bioconjugation: Serves as a precursor for reagents that attach small molecules, fluorophores, or affinity tags to biomolecules.
• Material Science: Potential use in creating photo-crosslinkable polymers and advanced surface coatings.
• Agrochemical Research: Employed in the study of herbicide and pesticide mode-of-action and target site identification.

Basic Information

Product Name	4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Aniline
CAS No.	1610689-08-1
Molecular Formula	C8H5F3N3
Molecular Weight	200.14 g/mol
Synonyms	3-[4-Aminophenyl]-3-(trifluoromethyl)-3H-diazirine; 4-(3-(Trifluoromethyl)diazirin-3-yl)aniline; 4-(3-Trifluoromethyl-3H-diazirin-3-yl)benzenamine; 4-(3-Trifluoromethyl-3H-diazirin-3-yl)phenylamine; 4-(3-Trifluoromethyl-diazirin-3-yl)-aniline; 4-(Trifluoromethyldiazirinyl)aniline; 4-Amino-3'-(trifluoromethyl)diazirine; p-(3-(Trifluoromethyl)-3H-diazirin-3-yl)aniline
EINECS	Contact for details

Quality Control

Our production of 4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Aniline adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. All materials are fully characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and development documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.