Description

(E)-Methyl 7-((1R,2R,3R,5S)-5-Acetoxy-2-((E)-4,4-Difluoro-3-Oxooct-1-En-1-Yl)-3-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Cyclopentyl)Hept-2-Enoate is a high-purity, advanced pharmaceutical intermediate characterized by its complex stereochemistry and functional groups. This compound is critical for enabling precise synthetic pathways in the development of novel therapeutic agents, particularly in prostaglandin and lipid mediator research. It serves as an essential building block for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries.

Application

• Key Intermediate in Prostaglandin Analog Synthesis: Used in the research and production of prostaglandin-based pharmaceuticals targeting ocular, cardiovascular, and gastrointestinal conditions.
• Medicinal Chemistry & Drug Discovery: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Process Chemistry & Scale-Up: Employed in the optimization and kilogram-scale production of active pharmaceutical ingredients (APIs) requiring specific stereochemical configurations.
• Biochemical Research: Utilized as a tool compound to study lipid signaling pathways and receptor interactions in academic and industrial research settings.
• Synthesis of Fluorinated Bioactive Molecules: The difluoro and enone motifs make it valuable for creating fluorinated drug candidates with enhanced metabolic stability and binding affinity.

Basic Information

Product Name	(E)-Methyl 7-((1R,2R,3R,5S)-5-Acetoxy-2-((E)-4,4-Difluoro-3-Oxooct-1-En-1-Yl)-3-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Cyclopentyl)Hept-2-Enoate
CAS No.	1610029-17-8
Molecular Formula	C28H42F2O7
Molecular Weight	528.64 g/mol
Synonyms	Methyl (E)-7-[(1R,2R,3R,5S)-5-Acetyloxy-2-[(E)-4,4-difluoro-3-oxooct-1-en-1-yl]-3-(oxan-2-yloxy)cyclopentyl]hept-2-enoate; Prostaglandin F2α THP Ether Acetate Methyl Ester Analog; Difluoroprostenoate Intermediate; 7-[(1R,2R,3R,5S)-5-Acetoxy-2-[(E)-4,4-difluoro-3-oxooct-1-enyl]-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]hept-2-enoic Acid Methyl Ester; PGF2α THP Derivative; CAS 1610029-17-8
EINECS	Contact for details

Quality Control

Our (E)-Methyl 7-((1R,2R,3R,5S)-5-Acetoxy-2-((E)-4,4-Difluoro-3-Oxooct-1-En-1-Yl)-3-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Cyclopentyl)Hept-2-Enoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the exacting standards required for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the certificate of analysis/label. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.