Description

1-Methyl-4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-1H-Pyrazole is a high-value boronic ester derivative, a crucial Suzuki-Miyaura cross-coupling reagent for constructing complex biaryl systems. Its primary value lies in enabling efficient carbon-carbon bond formation under mild conditions, which is fundamental for synthesizing advanced pharmaceutical intermediates and organic electronic materials. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity building blocks for their synthetic pipelines.

Application

• Pharmaceutical Intermediate Synthesis: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating complex biaryl and heterobiaryl motifs common in modern drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages for optimal biological activity.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for electron-transport materials and host materials in OLED devices, where precise molecular architecture is critical for performance.
• Polymer & Material Science: Employed in the synthesis of conjugated polymers and organic semiconductors for applications in flexible electronics and photovoltaics.
• Ligand & Catalyst Development: Acts as a versatile precursor for creating novel bidentate or tridentate ligands used in homogeneous catalysis.
• Chemical Biology & Probe Synthesis: Utilized to create labeled molecules and chemical probes for studying biological pathways and protein interactions.

Basic Information

Product Name	1-Methyl-4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-1H-Pyrazole
CAS No.	1607838-14-1
Molecular Formula	C16H21BN2O2
Molecular Weight	284.16 g/mol
Synonyms	1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-pyrazole; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-methyl-1H-pyrazole; 1-Methyl-4-(4-(pinacolatoboryl)phenyl)-1H-pyrazole; 1-Methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrazole; 1-Methyl-4-(p-pinacolatoborylphenyl)pyrazole; 1607838-14-1; 1-Methyl-4-(4-(pinacolboron)phenyl)pyrazole
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-1H-Pyrazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity and purity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring suitability for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture will compromise purity and reactivity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.