Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(4-(Trifluoromethoxy)Phenoxy)Pyrimidine is a high-purity, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is valued for its unique molecular structure, which incorporates both a pinacol boronate ester and a trifluoromethoxy-substituted phenoxy group, making it a critical reagent in modern cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in Suzuki-Miyaura cross-coupling reactions to form biaryl structures.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the stability and reactivity of the boronate ester group.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Synthesis: An essential reagent for medicinal chemists to introduce the 2-(4-(trifluoromethoxy)phenoxy)pyrimidine moiety into target molecules.
• Life Science Research: Employed in the discovery and optimization of bioactive compounds for various therapeutic targets.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(4-(Trifluoromethoxy)Phenoxy)Pyrimidine
CAS No.	1599467-81-8
Molecular Formula	C₁₇H₁₈BF₃N₂O₄
Molecular Weight	382.15 g/mol
Synonyms	2-(4-(Trifluoromethoxy)phenoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[4-(trifluoromethoxy)phenoxy]pyrimidine; 2-(4-Trifluoromethoxyphenoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Pyrimidine, 2-[4-(trifluoromethoxy)phenoxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; B-1599467-81-8
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(4-(Trifluoromethoxy)Phenoxy)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with global regulatory frameworks, including REACH and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.