Description

Ruphos Palladacycle Gen. 4 is a highly active, third-generation palladium precatalyst designed for robust cross-coupling reactions. Its significance lies in its exceptional stability and efficiency, enabling challenging transformations under mild conditions with low catalyst loadings. This advanced catalyst is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where reliable and scalable synthetic methodologies are critical.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key C-C and C-N bond formations in the synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Development: Facilitating the construction of complex heterocyclic and aromatic compounds for novel crop protection agents.
• Buchwald-Hartwig Amination: A premier catalyst for C-N cross-coupling reactions, including aryl amination with primary and secondary amines.
• Suzuki-Miyaura Coupling: Efficiently catalyzes the coupling of aryl/vinyl boronic acids with aryl/vinyl halides or pseudohalides.
• Academic & Process R&D: A valuable tool for methodology development and scaling up synthetic routes from lab to pilot plant.
• Materials Science: Used in the synthesis of conjugated polymers and organic electronic materials requiring precise molecular architecture.

Basic Information

Product Name	Ruphos Palladacycle Gen. 4
CAS No.	1599466-85-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	RuPhos Palladacycle Generation 4; Chloro(2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); RuPhos Pd G4; Pd-PEPPSI-IPentCl; Palladium(II) 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (3-chloropyridyl) complex; Third-Generation RuPhos Precatalyst; [RuPhos Pd(allyl)]Cl; Allyl(chloro)[2-(dicyclohexylphosphino)-2',6'-diisopropoxy-1,1'-biphenyl]palladium
EINECS	Contact for details

Quality Control

Our Ruphos Palladacycle Gen. 4 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to verify identity, purity, and the absence of deleterious impurities. Certificates of Analysis (COA) documenting full specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain long-term stability and prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Palladium (Pd) Content	Contact for details
Solubility	Soluble in common organic solvents (THF, DCM, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.