Description

Xphos Pd G4 CAS NO 1599466-81-5 is a highly active, third-generation palladium precatalyst featuring the bulky, electron-rich XPhos ligand, designed for superior performance in demanding cross-coupling reactions. This catalyst system offers exceptional stability and reactivity, enabling efficient synthesis under mild conditions with challenging substrates. It is an indispensable tool for researchers and process chemists in pharmaceutical development, agrochemical research, and advanced material science, where reliable and scalable catalytic transformations are critical.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key C–N, C–O, and C–C bond-forming reactions (e.g., Buchwald-Hartwig amination, Suzuki-Miyaura coupling) for API development.
• Agrochemical Manufacturing: Facilitating the construction of complex heterocyclic and biaryl compounds used in active ingredients.
• Material Science & OLED Research: Catalyzing cross-coupling reactions to create novel conjugated polymers and organic electronic materials.
• Process Chemistry & Scale-up: Ideal for transitioning from lab-scale discovery to pilot and commercial manufacturing due to its robustness.
• Academic & Industrial R&D: A premier catalyst for methodological development and exploring new chemical space in synthetic organic chemistry.
• Fine Chemical Production: Used in the synthesis of specialty chemicals, flavors, and fragrances requiring high selectivity.

Basic Information

Product Name	Xphos Pd G4
CAS No.	1599466-81-5
Molecular Formula	C₄₈H₆₆N₂P₂Pd
Molecular Weight	855.83 g/mol
Synonyms	Chloro(2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); Pd-PEPPSI-IPent(Cl); XPhos Pd G4; Palladium XPhos Generation 4 Precatalyst; XPhos Pd (II) Precatalyst; PEPPSI-IPent Palladium Complex; [2-(2-Aminoethyl)phenyl]chloro(2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)palladium
EINECS	Contact for details

Quality Control

Every batch of Xphos Pd G4 is manufactured and tested under strict quality management systems to ensure consistent, high-performance catalytic activity. Our rigorous quality testing includes advanced analytical techniques to verify identity, purity, and metal content, ensuring compliance with research and industrial standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent decomposition. The material is light-sensitive and easily oxidized; prolonged exposure to air, moisture, or ambient temperature should be avoided.

Specification

Item	Specification
Appearance	Yellow to orange-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Palladium (Pd) Content	Approx. 12.4%
Solubility	Soluble in common organic solvents (DCM, THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.