Description

5-Chloro-2-Fluoro-4-Methylacetophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in its unique halogen-substituted structure, which serves as a versatile intermediate for constructing complex molecules in regulated industries. This compound is primarily needed by research and development teams, as well as process chemists, in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic motifs for bioactivity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and chlorine atoms enhance compound stability and efficacy.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and halogen functionalities.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	5-Chloro-2-Fluoro-4-Methylacetophenone
CAS No.	1595747-83-3
Molecular Formula	C9H8ClFO
Molecular Weight	186.61 g/mol
Synonyms	1-(5-Chloro-2-fluoro-4-methylphenyl)ethanone; 5-Chloro-2-fluoro-4-methylacetophenone; 2-Fluoro-5-chloro-4-methylacetophenone; 4'-Methyl-2'-fluoro-5'-chloroacetophenone; 1-Acetyl-5-chloro-2-fluoro-4-methylbenzene; 2-Fluoro-4-methyl-5-chloroacetophenone; Acetophenone, 5-chloro-2-fluoro-4-methyl-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-4-Methylacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent quality suitable for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.