Description

2-Bromo-4-Methylphenylboronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form, which is critical for reliable performance in sensitive reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures via cross-coupling methodologies.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and organoboron compounds, enabling the synthesis of biaryl structures prevalent in active pharmaceutical ingredients (APIs) and functional materials.
• Pharmaceutical Intermediate Synthesis: Serves as a versatile building block in the research and development of novel drug candidates, particularly for creating substituted biphenyl and heterobiaryl cores.
• Agrochemical Compound Development: Used in the synthesis of advanced herbicides, fungicides, and insecticides that require specific bromo- and methyl-substituted aromatic motifs.
• Material Science & OLED Research: Employed in the construction of organic semiconductors, liquid crystals, and light-emitting materials where precise control over molecular structure is paramount.
• Chemical Biology & Probe Development: Useful for incorporating biaryl groups into molecular probes and tags for studying biological systems.
• Scale-up and Process Chemistry: The pinacol ester's stability makes it suitable for kilogram-scale manufacturing processes in fine chemical production.

Basic Information

Product Name	2-Bromo-4-Methylphenylboronic Acid Pinacol Ester
CAS No.	1595077-97-6
Molecular Formula	C₁₃H₁₈BBrO₂
Molecular Weight	297.00 g/mol
Synonyms	2-Bromo-4-methylbenzeneboronic acid pinacol ester; (2-Bromo-4-methylphenyl)boronic acid pinacol ester; 4-Methyl-2-bromophenylboronic acid pinacol ester; 2-Bromo-p-tolylboronic acid pinacol ester; Pinacol (2-bromo-4-methylphenyl)boronate; 2-Bromo-4-methylphenyl-Bpin; B-(2-Bromo-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of our 2-Bromo-4-Methylphenylboronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure it meets the high-purity standards required for synthetic applications. Our quality assurance protocols include chromatographic purity analysis and structural confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.