Description

2,2,2-Trifluoro-1-(Pyridin-3-Yl)Ethanone Hydrochloride is a high-purity trifluoromethyl ketone derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in its ability to introduce the metabolically stable trifluoromethyl group and a reactive ketone moiety into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Research: Used in the discovery and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials that require fluorine-containing motifs for improved performance.
• Chemical Biology Probe: Serves as a versatile scaffold for creating chemical probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2,2,2-Trifluoro-1-(Pyridin-3-Yl)Ethanone Hydrochloride
CAS No.	1588441-22-8
Molecular Formula	C8H5F3NO•HCl
Molecular Weight	215.59 g/mol (Free base: 179.13 g/mol)
Synonyms	3-(Trifluoroacetyl)pyridine Hydrochloride; 1-(3-Pyridinyl)-2,2,2-trifluoroethanone Hydrochloride; 3-Pyridyl Trifluoromethyl Ketone Hydrochloride; α,α,α-Trifluoro-3-pyridyl Methyl Ketone Hydrochloride; 3-(2,2,2-Trifluoroacetyl)pyridine HCl; TFAP-HCl; Pyridine-3-trifluoromethyl ketone hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(Pyridin-3-Yl)Ethanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to relevant standards for advanced intermediates, supporting our clients' needs for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.