Description

2-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole-3-Carbaldehyde is a high-value, organoboron-protected pyrazole aldehyde building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: The tetramethyl dioxaborolane (pinacol boronate ester) group serves as a stable, reactive handle for palladium-catalyzed coupling with aryl/heteroaryl halides.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the pyrazole core's bioactivity.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker or warhead component in the design of bifunctional degraders and other chemical probes.
• Academic & Contract Research: A valuable reagent for methodology development and complex natural product synthesis in research laboratories.

Basic Information

Product Name	2-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole-3-Carbaldehyde
CAS No.	1578484-85-1
Molecular Formula	C10H15BN2O3
Molecular Weight	222.06 g/mol
Synonyms	2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbaldehyde; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-2H-pyrazole-3-carbaldehyde; 2-Methyl-4-(pinacolatoboryl)-1H-pyrazole-3-carbaldehyde; 4-BPin-2-methyl-1H-pyrazole-3-carbaldehyde; 2-Methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carboxaldehyde; 1578484-85-1; 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-5-carbaldehyde (tautomer)
EINECS	Contact for details

Quality Control

Our 2-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole-3-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.