Description

1-(Oxetan-3-Ylmethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, multi-functional heterocyclic building block containing both a pyrazole core and a protected boronic ester moiety. This compound is critical for modern synthetic chemistry, enabling the construction of complex molecular architectures through versatile cross-coupling reactions. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for Suzuki-Miyaura cross-coupling reactions in the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require the incorporation of the pyrazole heterocycle.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the modular synthesis of bifunctional molecules for targeted protein degradation studies.
• Ligand and Catalyst Development: The pyrazole nitrogen atoms and boronic ester group make it a useful scaffold for designing novel ligands and organocatalysts.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and medicinal chemistry programs at research institutions and CROs.

Basic Information

Product Name	1-(Oxetan-3-Ylmethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1578484-07-7
Molecular Formula	C13H21BN2O3
Molecular Weight	264.13 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(oxetan-3-ylmethyl)-1H-pyrazole; 1-(Oxetan-3-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-(oxetan-3-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(oxetan-3-ylmethyl)pyrazole; 1-(Oxetan-3-ylmethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1578484-07-7; Oxetane-pyrazole boronic ester; 3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)oxetane
EINECS	Contact for details

Quality Control

Our 1-(Oxetan-3-Ylmethyl)-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.