Description

(2-(Difluoromethyl)Pyridin-4-Yl)Boronic Acid is a high-value organoboron building block, specifically a pyridine-containing boronic acid derivative. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic chemistry for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce the difluoromethylpyridine moiety into target structures, a key strategy for modulating the physicochemical and biological properties of new chemical entities.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethylpyridine group can enhance bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, metal-organic frameworks (MOFs), and functional polymers via cross-coupling methodologies.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	(2-(Difluoromethyl)Pyridin-4-Yl)Boronic Acid
CAS No.	1571135-77-7
Molecular Formula	C6H6BF2NO2
Molecular Weight	172.93 g/mol
Synonyms	4-(Difluoromethyl)pyridine-2-boronic acid; 2-(Difluoromethyl)-4-pyridineboronic acid; (2-(Difluoromethyl)-4-pyridinyl)boronic acid; 4-Pyridineboronic acid, 2-(difluoromethyl)-; B-[2-(Difluoromethyl)-4-pyridinyl]boronic acid; (2-Difluoromethylpyridin-4-yl)boronic acid
EINECS	Contact for details

Quality Control

Our (2-(Difluoromethyl)Pyridin-4-Yl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.