Description

4-(2,5-Difluoro-Phenyl)-But-3-En-2-One is a high-purity fluorinated organic building block, specifically an α,β-unsaturated ketone with a difluorophenyl substituent. This compound is valued for its role as a versatile synthetic intermediate in advanced organic synthesis, where its unique fluorine atoms and reactive enone moiety enable precise molecular construction. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic electronic materials.
• Fluorine Chemistry: An essential reagent for introducing the difluorophenyl group into target molecules, facilitating structure-activity relationship (SAR) studies.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions, such as Heck or Suzuki couplings, for carbon-carbon bond formation.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and the exploration of new chemical spaces.

Basic Information

Product Name	4-(2,5-Difluoro-Phenyl)-But-3-En-2-One
CAS No.	1571074-31-1
Molecular Formula	C10H8F2O
Molecular Weight	182.17 g/mol
Synonyms	1-(2,5-Difluorophenyl)-3-buten-2-one; 4-(2,5-Difluorophenyl)but-3-en-2-one; (E)-4-(2,5-Difluorophenyl)but-3-en-2-one; 2,5-Difluorochalcone; 3-Buten-2-one, 1-(2,5-difluorophenyl)-; 4-(2,5-Difluorophenyl)-3-buten-2-one; DFB; 2,5-DFBP
EINECS	Contact for details

Quality Control

Our production of 4-(2,5-Difluorophenyl)-But-3-En-2-One adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, GC, NMR, and IR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under cGMP guidelines and can tailor specifications to meet the rigorous demands of pharmaceutical regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.