Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Naphthol is a high-purity, functionalized naphthol derivative containing a pinacol boronate ester group, making it a versatile and valuable advanced pharmaceutical intermediate and organic synthesis building block. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in pharmaceutical R&D, agrochemical synthesis, and materials science who require reliable, high-quality boronic ester reagents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drug candidates targeting oncology and central nervous system disorders.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to introduce the naphthol moiety into complex organic molecules, facilitating the creation of biaryl and heterobiaryl structures prevalent in modern medicinal chemistry.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Organic Light-Emitting Diodes (OLEDs) Research: Serves as a precursor for constructing complex organic semiconductors and light-emitting materials.
• Ligand and Catalyst Development: Used to create novel bidentate or polydentate ligands for transition metal catalysis.
• Polymer and Material Science: Building block for synthesizing functionalized polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Item	Details
Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Naphthol
CAS No.	1560648-02-3
Molecular Formula	C₁₆H₂₁BO₃
Molecular Weight	272.15 g/mol
Synonyms	1-Naphthol-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-ol; 4-(Pinacolatoboryl)-1-naphthol; 4-(1,3,2-Dioxaborolan-2-yl)-1-naphthol (pinacol ester); 4-Borono-1-naphthol pinacol ester; 4-Hydroxy-1-naphthaleneboronic acid pinacol ester; PINACOL 4-HYDROXY-1-NAPHTHALENEBORONATE
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Naphthol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing the specifications and test results is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.