Description

3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrrolo[3,2-B]Pyridine is a high-value, heterocyclic boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its primary commercial value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This advanced pharmaceutical intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly in the development of novel active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS, and antiviral drug candidates.
• Suzuki-Miyaura Cross-Coupling: Essential boron reagent for palladium-catalyzed C-C bond formation to create biaryl and heterobiaryl structures.
• Agrochemical Research: Building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science & OLEDs: Used in the synthesis of organic semiconductors, light-emitting materials, and charge-transport layers for electronic devices.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Facilitates the modular construction of bifunctional molecules for targeted protein degradation.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis of diverse compound libraries for screening.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrrolo[3,2-B]Pyridine
CAS No.	1558927-10-8
Molecular Formula	C15H19BN2O2
Molecular Weight	270.14 g/mol
Synonyms	1H-Pyrrolo[3,2-b]pyridine, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[3,2-b]pyridine; 3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[3,2-b]pyridine; 3-Pinacolatoboryl-1H-pyrrolo[3,2-b]pyridine; 3-Boronic acid pinacol ester of 1H-pyrrolo[3,2-b]pyridine; CAS 1558927-10-8
EINECS	Contact for details

Quality Control

Our production of 3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrrolo[3,2-B]Pyridine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR (1H, 13C, 11B) for structural confirmation, and mass spectrometry. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.