Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-Trifluoromethyl-1H-Indole is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. Its core value lies in its unique molecular architecture, combining a protected boronic ester with a trifluoromethyl-substituted indole scaffold, enabling efficient cross-coupling reactions and the introduction of fluorine-containing motifs. This compound is essential for researchers and manufacturers in medicinal chemistry and agrochemical development, particularly for constructing complex molecules via Suzuki-Miyaura coupling.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Medicinal Chemistry Research: Used in drug discovery for the construction of novel indole-based compounds and the introduction of the trifluoromethyl group to modulate pharmacokinetic properties.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester functionality serves as a stable handle for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Agrochemical Synthesis: Employed in the development of new crop protection agents and herbicides that benefit from fluorine-containing structures.
• Material Science: Potential building block for creating functional organic materials and ligands for catalysis.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological systems.

Basic Information

Item	Detail
Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-Trifluoromethyl-1H-Indole
CAS No.	1557138-33-6
Molecular Formula	C15H17BF3NO2
Molecular Weight	311.11 g/mol
Synonyms	6-(Trifluoromethyl)-1H-indole-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-1H-indole; 6-Trifluoromethyl-1H-indole-2-boronic acid pinacol ester; 2-Borono-6-trifluoromethylindole pinacol ester; 1557138-33-6; 6-CF3-1H-Indole-2-Bpin
EINECS	Contact for details

Quality Control

Every batch of 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-Trifluoromethyl-1H-Indole is manufactured under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency through comprehensive analytical testing, including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.