Description

1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene]Sulfonyl}Piperidine is a high-value, organoboron-based chemical building block designed for advanced synthetic applications. Its core value lies in the combination of a protected boronic ester group and a sulfonyl piperidine moiety, enabling precise cross-coupling reactions and serving as a key intermediate in complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients through Suzuki-Miyaura coupling and other palladium-catalyzed transformations.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in creating complex biaryl and heterobiaryl structures common in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require the incorporation of specific aromatic and heterocyclic systems.
• Material Science Research: Serves as a monomer or precursor in the development of advanced organic electronic materials, such as polymers for OLEDs or organic photovoltaics.
• Suzuki-Miyaura Cross-Coupling: The tetramethyl dioxaborolane (pinacol boronic ester) group provides excellent stability and reactivity for palladium-catalyzed cross-coupling with aryl halides, a cornerstone reaction in modern organic synthesis.
• Chemical Biology & Proteomics: Can be utilized as a versatile handle for bioconjugation or as part of chemical probes designed to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: An important starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene]Sulfonyl}Piperidine
CAS No.	1548827-83-3
Molecular Formula	C17H26BNO4S
Molecular Weight	351.27 g/mol
Synonyms	4-(Piperidine-1-sulfonyl)phenylboronic acid pinacol ester; 1-[(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl]piperidine; 4-(N-Piperidinosulfonyl)phenylboronic acid pinacol ester; [4-(Piperidine-1-sulfonyl)phenyl]boronic acid pinacol ester; Pinacol [4-(piperidine-1-sulfonyl)phenyl]boronate; 1-({4-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)]phenyl}sulfonyl)piperidine; B-[4-(1-Piperidinosulfonyl)phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene]Sulfonyl}Piperidine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling reactions. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality system is designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.