Description

2-(N,n-Dimethylamino)-3-Fluoropyridine-5-Boronic Acid Pinacol Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its core value lies in its dual functionality as a protected boronic acid ester and a halogenated heterocyclic amine, enabling precise cross-coupling reactions and molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boronic ester reagent for forming carbon-carbon bonds in the construction of biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require fluorinated pyridine scaffolds for enhanced activity and stability.
• Material Science & OLED Development: Employed in the creation of novel organic electronic materials, including ligands for catalysts and components for light-emitting diodes (OLEDs).
• Chemical Biology & Probe Synthesis: Facilitates the labeling and modification of biomolecules for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific, high-value fluorinated heterocycles.

Basic Information

Product Name	2-(N,n-Dimethylamino)-3-Fluoropyridine-5-Boronic Acid Pinacol Ester Hydrochloride
CAS No.	1548827-81-1
Molecular Formula	C13H19BFN2O2 • HCl
Molecular Weight	300.57 g/mol (Free base: 264.11 g/mol)
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-fluoro-2-(dimethylamino)pyridine hydrochloride; 2-(Dimethylamino)-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine hydrochloride; 3-Fluoro-2-(dimethylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine HCl; 2-Dimethylamino-3-fluoro-5-pyridineboronic acid pinacol ester hydrochloride; (3-Fluoro-2-(dimethylamino)pyridin-5-yl)boronic acid pinacol ester hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(N,n-Dimethylamino)-3-Fluoropyridine-5-Boronic Acid Pinacol Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.