Description

3-Fluorocyclobutanecarboxylic Acid Methyl Ester is a high-value fluorinated cyclobutane derivative, serving as a critical building block in modern synthetic chemistry. Its unique strained-ring structure combined with a fluorine substituent makes it an essential intermediate for developing novel pharmaceuticals and advanced materials. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the fluorocyclobutane moiety can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Building block for fluorinated polymers and liquid crystals, imparting unique electronic and physical properties.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes and tags for studying biological systems and protein interactions.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of fluorinated target molecules.

Basic Information

Product Name	3-Fluorocyclobutanecarboxylic Acid Methyl Ester
CAS No.	1547065-03-1
Molecular Formula	C7H11FO2
Molecular Weight	146.16 g/mol
Synonyms	Methyl 3-Fluorocyclobutanecarboxylate; 3-Fluorocyclobutanecarboxylic Acid Methyl Ester; 3-Fluorocyclobutane-1-carboxylic Acid Methyl Ester; Methyl 3-Fluorocyclobutane-1-carboxylate; 3-Fluoro-1-cyclobutanecarboxylic Acid Methyl Ester; 1547065-03-1; 3-Fluorocyclobutanecarboxylic acid, methyl ester
EINECS	Contact for details

Quality Control

Every batch of 3-Fluorocyclobutanecarboxylic Acid Methyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are aligned with industry best practices for fine chemical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles as determined by validated methods including GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.