Description

3-(Fluoromethyl)Oxetane-3-Carboxylic Acid is a high-value, multifunctional building block characterized by its oxetane ring and carboxylic acid group, offering unique reactivity for advanced molecular synthesis. This compound is critical for introducing both fluorinated motifs and strained heterocyclic systems into target molecules, enabling the fine-tuning of physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, polymer science, and the development of novel materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluoromethyl-oxetane motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the fluorinated oxetane structure can improve efficacy and environmental profile.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polymers with tailored properties such as modified surface energy, chemical resistance, or specific degradation profiles.
• Ligand & Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Fluorine Chemistry Research: A valuable substrate for exploring new fluorination methodologies and studying the effects of fluorine substitution on molecular conformation and reactivity.
• Bioconjugation & Probe Synthesis: Useful for creating chemical probes, tags, and linkers in bioconjugation chemistry due to its reactive carboxylic acid handle and fluorinated tag.

Basic Information

Product Name	3-(Fluoromethyl)Oxetane-3-Carboxylic Acid
CAS No.	1545011-97-9
Molecular Formula	C5H7FO3
Molecular Weight	134.11 g/mol
Synonyms	3-(Fluoromethyl)-3-oxetanecarboxylic acid; 3-Carboxy-3-(fluoromethyl)oxetane; Oxetane-3-carboxylic acid, 3-(fluoromethyl)-; 3-Fluoromethyl-3-oxetanecarboxylic acid; 3-(Fluoromethyl)oxetane-3-carboxylic acid; 3-Oxetanecarboxylic acid, 3-(fluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3-(Fluoromethyl)Oxetane-3-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, NMR, and GC is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.