Description

[4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methanamine is a high-value, multifunctional organic building block featuring both a primary amine and a protected boronic ester group. This compound is essential for advanced organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and materials science sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used to construct novel herbicide and pesticide molecules, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Materials Science Research: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The pinacol boronic ester group is specifically designed for efficient, palladium-catalyzed Suzuki-Miyaura cross-coupling with aryl halides.
• Chemical Biology & Proteomics: The amine functionality allows for further derivatization, making it useful for creating probes, linkers, and bioconjugates.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry programs.

Basic Information

Product Name	[4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methanamine
CAS No.	1544673-68-8
Molecular Formula	C₁₃H₁₉BFNO₂
Molecular Weight	251.10 g/mol
Synonyms	(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine; 2-(4-(Aminomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine; 2-(4-(Aminomethyl)-2-fluorophenyl)-1,3,2-dioxaborinane, 4,4,5,5-tetramethyl-; 1544673-68-8; 4-Fluoro-3-(pinacolatoboron)benzylamine; (3-(Aminomethyl)-4-fluorophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our [4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methanamine is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP requirements for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.