Description

4-(4-Chloro-2-Fluorophenyl)Butan-2-One is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical R&D departments engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for electronic display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, carbonyl chemistry, and as a precursor for heterocyclic compounds like pyrroles and indoles.
• Chemical Research & Development: Essential for academic and industrial labs exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	4-(4-Chloro-2-Fluorophenyl)Butan-2-One
CAS No.	1540370-13-5
Molecular Formula	C10H10ClFO
Molecular Weight	200.64 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-3-butanone; 4-Chloro-2-fluorophenylacetone; 4'-Chloro-2'-fluoro-3-butanophenone; 3-Oxo-1-(4-chloro-2-fluorophenyl)butane; Butan-2-one, 4-(4-chloro-2-fluorophenyl)-; 4-(4-Chloro-2-fluorophenyl)-2-butanone
EINECS	Contact for details

Quality Control

Every batch of 4-(4-Chloro-2-Fluorophenyl)Butan-2-One is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), identity confirmation (by IR and NMR), and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.