Description

1-(6-Bromo-3-Chloro-2-Fluorophenyl)Ethanone is a high-purity halogenated aromatic ketone building block of significant importance in advanced organic synthesis. This compound is valued for its precise molecular architecture, which enables the introduction of multiple halogen substituents in a defined spatial arrangement, a critical feature for modulating the biological activity and physicochemical properties of target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the bromo, chloro, and fluoro groups contribute to binding affinity and environmental stability.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and advanced polymers with specific optical or electronic properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct more complex biaryl systems.
• Functional Group Transformation: The ketone moiety allows for further derivatization into alcohols, alkenes, amines, and heterocycles, expanding its utility in medicinal chemistry.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	1-(6-Bromo-3-Chloro-2-Fluorophenyl)Ethanone
CAS No.	1540199-39-0
Molecular Formula	C8H5BrClFO
Molecular Weight	251.48 g/mol
Synonyms	2'-Fluoro-6'-bromo-3'-chloroacetophenone; 1-Acetyl-6-bromo-3-chloro-2-fluorobenzene; 6-Bromo-3-chloro-2-fluoroacetophenone; Ethanone, 1-(6-bromo-3-chloro-2-fluorophenyl)-; 2-Fluoro-6-bromo-3-chloroacetophenone; 3-Chloro-6-bromo-2-fluoroacetophenone; (6-Bromo-3-chloro-2-fluorophenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 1-(6-Bromo-3-Chloro-2-Fluorophenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.