Description

2,4,5-Trifluorobenzothioamide is a high-purity fluorinated aromatic thioamide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl and thioamide functionalities are crucial for modulating biological activity and physicochemical properties. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors engaged in the synthesis of novel heterocyclic compounds and fluorinated molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a monomer or precursor for developing advanced polymers and organic electronic materials with specific optoelectronic properties.
• Chemical Biology & Proteomics: Employed as a reactive handle or probe in the study of enzyme mechanisms and protein labeling due to the thioamide functionality.
• Ligand Synthesis for Catalysis: Utilized in the preparation of specialized ligands for transition metal catalysis, enabling novel synthetic transformations.
• Fluorinated Compound Library: A valuable reagent for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	2,4,5-Trifluorobenzothioamide
CAS No.	1537764-75-2
Molecular Formula	C7H4F3NS
Molecular Weight	191.18 g/mol
Synonyms	2,4,5-Trifluorobenzenecarbothioamide; Benzothioamide, 2,4,5-trifluoro-; 2,4,5-Trifluorobenzene-1-carbothioamide; 2,4,5-Trifluorothiobenzamide; 1537764-75-2; AI3-52362; ZINC000103014509; AKOS040759623; FT-0775787; EN300-264614
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluorobenzothioamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, extended exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.