Description

tert-Butyl 4-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridyl]-3,6-Dihydro-2H-Pyridine-1-Carboxylate is a high-value, protected boronic ester derivative, serving as a critical advanced pharmaceutical intermediate (API) and Suzuki-Miyaura cross-coupling reagent. Its primary value lies in enabling the efficient synthesis of complex, functionalized heterocyclic scaffolds essential for modern drug discovery. This compound is specifically designed for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries who require reliable, high-purity building blocks for constructing novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds between the boronic ester and aryl/heteroaryl halides under palladium catalysis.
• Medicinal Chemistry & Drug Discovery: Used in library synthesis for structure-activity relationship (SAR) studies and lead optimization.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science: Potential precursor for creating organic electronic materials and functional polymers.
• Chemical Biology: Tool compound for probe and conjugate synthesis due to its reactive boronate functionality.

Basic Information

Product Name	tert-Butyl 4-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridyl]-3,6-Dihydro-2H-Pyridine-1-Carboxylate
CAS No.	1534381-85-5
Molecular Formula	C21H31BN2O4
Molecular Weight	386.29 g/mol
Synonyms	1-Boc-4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-1,2,3,6-tetrahydropyridine; tert-Butyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate; 1,2,3,6-Tetrahydro-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)-1-pyridinecarboxylic acid 1,1-dimethylethyl ester; 2-(1-Boc-1,2,3,6-tetrahydropyridin-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 1534381-85-5; BOC-protected pyridyl boronic ester pinacol ester.
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Quality Control

Our tert-Butyl 4-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridyl]-3,6-Dihydro-2H-Pyridine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.