Description

tert-Butyl 4-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is essential for facilitating efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly within therapeutic areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug candidates, especially those containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile coupling partner for the formation of carbon-carbon bonds between aromatic rings, enabling rapid library synthesis for drug discovery.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential APIs during late-stage research and development.
• Chemical Biology Probes: Can be utilized to create labeled or tagged molecules for studying biological pathways and target engagement.
• Material Science Research: Potential precursor for the synthesis of organic electronic materials or ligands for catalysts, leveraging its piperazine and boronate ester functionalities.

Basic Information

Item	Detail
Product Name	tert-Butyl 4-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate
CAS No.	1534377-96-2
Molecular Formula	C21H32BFN2O4
Molecular Weight	406.30 g/mol
Synonyms	2-Fluoro-4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylboronic acid pinacol ester; 1-Boc-4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine; tert-Butyl 4-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate; 1534377-96-2; BOC-piperazine-boronate ester; 4-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.