Description

Methyl 3-(3,5-Difluorophenyl)-3-Oxopropionate is a high-purity fluorinated organic building block essential for advanced chemical synthesis. This compound serves as a critical intermediate in the development of complex molecules, offering a versatile β-ketoester functionality for further derivatization. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the discovery and production of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the difluorophenyl moiety enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialty polymers with unique optical or electronic properties.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reactions, such as cyclizations and condensations, leveraging its reactive carbonyl groups.
• Ligand and Catalyst Development: Utilized as a starting material for synthesizing complex chelating ligands used in asymmetric catalysis.

Basic Information

Product Name	Methyl 3-(3,5-Difluorophenyl)-3-Oxopropionate
CAS No.	1530834-98-0
Molecular Formula	C10H8F2O3
Molecular Weight	214.17 g/mol
Synonyms	Methyl 3,5-Difluorobenzoylacetate; 3-Oxo-3-(3,5-difluorophenyl)propanoic Acid Methyl Ester; Methyl 3-(3,5-Difluorobenzoyl)propionate; 3,5-Difluorophenyl 3-Oxopropanoate Methyl Ester; Methyl β-Oxo-3,5-difluorohydrocinnamate; Acetic acid, 2-(3,5-difluorobenzoyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-(3,5-Difluorophenyl)-3-Oxopropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled accordingly. Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.