Description

2-(3-Benzyloxy-5-Fluoro-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity boronic ester derivative, a critical advanced intermediate in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals. The CAS number for this product is 1528757-88-1.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing fluorinated biaryl motifs, used in drug discovery and development.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Used in the synthesis of organic electronic materials, such as ligands for OLEDs and other fluorinated polymers or small molecules.
• Cross-Coupling Reactions: A specialized reagent for Suzuki-Miyaura cross-coupling, facilitating carbon-carbon bond formation under mild conditions with high selectivity.
• Chemical Biology Probes: Serves as a precursor for creating fluorinated probes and tags used in biochemical assays and diagnostic research.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	2-(3-Benzyloxy-5-Fluoro-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	1528757-88-1
Molecular Formula	C19H22BFO3
Molecular Weight	328.19 g/mol
Synonyms	(3-(Benzyloxy)-5-fluorophenyl)boronic acid pinacol ester; 5-Fluoro-3-(phenylmethoxy)benzeneboronic acid pinacol ester; 2-(3-(Benzyloxy)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Benzyloxy-5-fluorophenylboronic acid pinacol ester; Pinacol (3-(benzyloxy)-5-fluorophenyl)boronate; B-[3-(Benzyloxy)-5-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(3-Benzyloxy-5-Fluoro-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP and ISO standards for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent hydrolysis. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.