Description

4-[2-Nitro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Morpholine is a high-value, synthetically versatile boronic ester derivative. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a key building block in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those targeting CNS disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds for constructing biaryl structures common in advanced materials and agrochemicals.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Building block for organic light-emitting diodes (OLEDs), liquid crystals, and polymers with specific electronic properties.
• Chemical Biology & Proteomics: Serves as a probe or linker in activity-based protein profiling and bioconjugation strategies.
• Academic & Process R&D: Employed in methodological studies and scale-up process development for new synthetic routes.

Basic Information

Product Name	4-[2-Nitro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Morpholine
CAS No.	1527471-35-7
Molecular Formula	C16H23BN2O5
Molecular Weight	334.18 g/mol
Synonyms	2-(4-Morpholino-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[4-morpholino-3-nitrophenyl]-1,3,2-dioxaborolane; 2-(4-Morpholin-4-yl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(2-Nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine; PINACOL (4-MORPHOLINO-3-NITROPHENYL)BORONATE; (4-Morpholino-3-nitrophenyl)boronic acid pinacol ester; Boronic acid, B-(4-morpholino-3-nitrophenyl)-, pinacol ester.
EINECS	Contact for details

Quality Control

Our 4-[2-Nitro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Morpholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed specifications, and our quality protocols are designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.